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采用ＲＩＡ法对５８例良、恶性胸腔积液中ＥＧＦ与ＴＮＦ进行含量检测。结果显示２２例良性胸水中ＥＧＦ与ＴＮＦ含量分别为２．０３±０．３５μｇ／Ｌ，１．６３±０．５４μｇ／Ｌ。３６例恶性胸水中ＥＧＦ与ＴＮＦ含量分别为１．２５±０．３２μｇ／Ｌ，１．０２±０．２４μｇ／Ｌ。良性胸水组ＥＧＦ与ＴＮＦ浓度均明显高于恶性胸水组，两组间有显著性差异，（Ｐ＜０．０５）。结果表明ＥＧＦ与ＴＮＦ均参与了良、恶性胸腔积液的免疫病理生理过程。
The contents of EGF and TNF in 58 cases of benign and malignant pleural effusion were detected by RIA method. The results showed that the content of EGF and TNF in 22 cases of benign pleural effusion were 2.03 ± 0.35μg / L and 1.63 ± 0.54μg / L, respectively. The contents of EGF and TNF in 36 cases of malignant pleural effusion were 1.25 ± 0.32μg / L and 1.02 ± 0.24μg / L, respectively. The concentrations of EGF and TNF in benign pleural effusion group were significantly higher than those in malignant hydrothorax group, with significant difference between the two groups (P <0.05). The results show that EGF and TNF are involved in the immune pathophysiological process of benign and malignant pleural effusion.