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目的：观察和探讨缰核细胞膜上延迟整流钾电流（Ｉｋ）的性质。方法：应用细胞吸附式膜片钳记录技术。结果：去极化阶跃电压激活该通道电导为３０～３５ｐＳ的外向单通道电流；呈电压依赖性；平均开放时间随去极化电位的增长（０ｍＶ～６０ｍＶ）由３．７２±１．５ｍｓ提高到３２．２±５．６ｍｓ。可以认为，通道的开放不依赖于电极内Ｃａ２＋的存在，四乙基胺明显抑制通道的开放。结论：由以上结果判断，此电流为外向延迟整流钾电流（Ｉｋ）。
Objective: To observe and discuss the properties of delayed rectifier potassium current (Ik) on the membrane of hamster nucleus. Methods: Cell-mount patch-clamp recording technique was used. Results: The depolarization step voltage activated the outward single channel current with 30 ~ 35pS conductance in a voltage dependent manner. The average open time increased with the increase of depolarization potential (0mV ~ 60mV) from 3.72 ± 1.5ms Increase to 32.2 ± 5.6ms. It is believed that the opening of the channel does not depend on the presence of Ca2 + in the electrode, and tetraethylamine significantly inhibits the opening of the channel. Conclusion: Judged by the above results, this current is outward delayed rectifier potassium current (Ik).