在抗骨质疏松药物的设计中，根据电子等排原理和药物的构效关系理论，设计并同时合成了７羟基３苯基４（１Ｈ）喹啉酮新衍生物以及其同分异构体５羟基３苯基４（１Ｈ）喹啉酮新衍生物．本文报道上述新化合物的１Ｈ ＮＭＲ 数据 In the design of anti-osteoporosis drugs, new derivatives of 7-hydroxy-3-phenyl-4 (1H) quinolinone were designed and synthesized according to the theory of electron isostere and the structure-activity relationship of drugs Isomer 5-hydroxy  3  phenyl  4 (1H)  quinolinone derivatives. The 1H NMR data of these new compounds are reported in this paper