充足的血供是维持细胞正常生命活动的前提,也是颌骨缺损区组织再生的必要条件。既往同体或异体骨组织移植存在来源不足、免疫排斥、二次创伤及潜在疾病感染等缺陷,而传统组织工程化骨植入后往往由于血供不足导致失败[1,2]。低氧诱导因子1(hypoxia induible factor l,HIF-1)的发 Adequate blood supply is to maintain the normal life and cell activity of the premise, but also the necessary conditions for tissue regeneration of the defect area of ​​the jaw. Previous or allogeneic bone transplantation has the defects of insufficient source, immune rejection, secondary trauma and potential disease infection. However, traditional tissue-engineered bone implants often fail due to inadequate blood supply [1,2]. Development of hypoxia inductive factor 1 (HIF-1)