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研究CD44v6mRNA和nm2 3H1mRNA表达与肝细胞癌 (HCC)侵袭转移和预后关系。应用原位杂交方法 ,检测分析HCC组织中CD44v6mRNA和nm2 3HmRNA表达。 99例HCC中 ,CD44v6mRNA和nm2 3H1mRNA表达阳性率分别为 41 4 %和 76 8%。CD44v6mRNA表达与nm2 3H1mRNA表达呈负相关。CD44v6和nm2 3H1mRNA表达均与HCC侵袭转移倾向和预后相关。检测CD44v6和nm2 3H1表达有可能成为HCC侵袭转移和预后判断的病理生物学指标。
To study the relationship between the expression of CD44v6 mRNA and nm23H1mRNA and the invasion, metastasis and prognosis of hepatocellular carcinoma (HCC). In situ hybridization was used to detect the expression of CD44v6 mRNA and nm23H mRNA in HCC tissues. The positive rates of CD44v6 mRNA and nm23H1 mRNA in 41 cases of HCC were 41 4% and 76 8%, respectively. The expression of CD44v6 mRNA was negatively correlated with the expression of nm23H1mRNA. Both the expression of CD44v6 and nm2 3H1mRNA were correlated with the invasion and metastasis and prognosis of HCC. Detection of CD44v6 and nm2 3H1 expression may be a pathological biological indicator of HCC invasion and metastasis and prognosis.