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目的验证血细胞参数RPR和P2/MS对乙型肝炎肝硬化的预测价值,并与其他一些指标比较。方法选取乙型肝炎肝硬化患者304名(LC组)、慢性乙型肝炎患者212例(CHB组),采用Sysmex XE-2100血细胞分析仪进行血常规检测;采用西门子Advia2400进行肝生化检测。根据公式RPR=RDW(%)/PLT(109/L)和P2/MS=[PLT(109/L)]2/[M(%)×S(%)]计算所有对象的RPR和P2/MS值,同时计算其AAR、APRI和FIB-4值。结果 LC组RPR中位数为0.22,显著高于CHB组的0.09;LC组P2/MS中位数为11.06,显著低于CHB组的73.02。ROC曲线分析显示,RPR和P2/MS诊断LC的曲线下面积(AUC)分别为0.883和0.879,差异无统计学意义(P>0.05)。两者AUC与FIB-4(0.884)比较差异均无统计学意义;而均显著高于AAR(0.799)和APRI(0.681)。结论 RPR和P2/MS均对乙型肝炎肝硬化具有一定的预测价值,且诊断准确度相近。
Objective To verify the predictive value of hematopoietic parameters RPR and P2 / MS for hepatitis B cirrhosis and compare with other indexes. Methods Totally 304 patients with liver cirrhosis (LC group) and 212 patients with chronic hepatitis B (CHB group) were enrolled in the study. Blood samples were collected by Sysmex XE-2100 hematology analyzer. Liver biochemistry was performed with Siemens Advia2400. RPR and P2 / MS for all objects are calculated according to the formulas RPR = RDW (%) / PLT (109 / L) and P2 / MS = [PLT (109 / L)] 2 / [M (%) × S Value while calculating its AAR, APRI, and FIB-4 values. Results The median RPR of LC group was 0.22, which was significantly higher than that of CHB group (0.09). The median P2 / MS of LC group was 11.06, which was significantly lower than that of CHB group (73.02). ROC curve analysis showed that the area under the curve (AUC) of RPR and P2 / MS in diagnosing LC were 0.883 and 0.879, respectively, with no significant difference (P> 0.05). There was no significant difference between AUC and FIB-4 (0.884), but significantly higher than AAR (0.799) and APRI (0.681). Conclusion Both RPR and P2 / MS have some predictive value for the diagnosis of cirrhosis of hepatitis B, and the diagnostic accuracy is similar.