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目的探讨血清内脂素与妊娠期糖尿病(GDM)并发子痫前期的关系。方法 ELISA法检测GDM并发子痫前期孕妇(A组,12例)、GDM无子痫前期孕妇(B组,30例)和正常孕妇(C组,50例)外周血清内脂素浓度;并测定三组孕妇的平均动脉压(MAP)、空腹胰岛素(FIns)、空腹血糖(FBG)、甘油三酯(TG)、总胆固醇(TC),计算胰岛素抵抗指数(HOMA-IR)和体重指数(BMI),分析血清内脂素水平与GDM并发子痫前期的关系。结果 A组血清内脂素、FIns和HOMA-IR均高于B组(P<0.05),B组高于C组(P<0.01)。多元回归分析显示,血清FIns水平是影响血清内脂素的重要因素。结论 GDM并发子痫前期孕妇血清内脂素水平明显升高,且与胰岛素抵抗有关。
Objective To investigate the relationship between serum visfatin and gestational diabetes mellitus (GDM) complicated with preeclampsia. Methods Serum lipids in peripheral blood of GDM complicated with preeclampsia (A group, 12 cases), GDM without preeclampsia (B group, 30 cases) and normal pregnant women (C group, 50 cases) were detected by ELISA. The mean arterial pressure (MAP), fasting insulin (FIns), fasting blood glucose (FBG), triglyceride (TG), total cholesterol (TC), calculated insulin resistance index (HOMA-IR) and body mass index ), Analysis of serum visfatin levels and GDM complicated with preeclampsia. Results The serum visfatin, FIns and HOMA-IR in group A were higher than those in group B (P <0.05), and those in group B were higher than those in group C (P <0.01). Multiple regression analysis showed that serum FIns level is an important factor affecting serum visfatin. Conclusions The level of serum visfatin in pregnant women with GDM complicated with preeclampsia is significantly increased, which is related to insulin resistance.