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目的研究早期急性脑梗死的急诊溶栓效果及安全性。方法将我院90例患者分为观察组与对照组,对照组仅采取低分子量肝素钠注射液抗凝治疗,观察组在其基础上采取尿激素溶栓治疗,比较两组临床疗效及神经功能缺损(HINSS)、日常生活能力量表(Barthel)。结果观察组总有效率为97.78%与对照组84.44%比较显著较高(P<0.05);观察组治疗后1、10d NIHSS评分分别为17.36±4.07、11.32±2.12分,显著低于对照组的22.36±4.38、16.36±2.58分,观察组治疗后1、10d Barthel分别为73.25±12.05、86.58±12.47分,与对照组60.34±11.58、71.36±10.43分比较显著较高,对比差异显著(P<0.05)。结论早期脑梗死急诊尿激酶溶栓治疗效果显著,安全性较高,具有较高的临床应用价值。
Objective To study the emergency thrombolytic effect and safety of early acute cerebral infarction. Methods Ninety patients in our hospital were divided into observation group and control group. The control group received low-molecular-weight heparin sodium injection anticoagulant therapy only. The observation group was given thrombolysis on the basis of urinary hormone. The clinical efficacy and neurological function were compared between the two groups Defect (HINSS), daily living ability scale (Barthel). Results The total effective rate in the observation group was 97.78%, which was significantly higher than that in the control group (84.44%) (P <0.05). The NIHSS scores of the observation group were 17.36 ± 4.07 and 11.32 ± 2.12 respectively at 1 and 10 days after treatment, which were significantly lower than those in the control group 22.36 ± 4.38 and 16.36 ± 2.58 respectively. The Barthel scores of the observation group at 1 and 10 days after treatment were 73.25 ± 12.05 and 86.58 ± 12.47 points, which were significantly higher than those of the control group (60.34 ± 11.58 and 71.36 ± 10.43 points, P < 0.05). Conclusions Urokinase thrombolytic therapy in early stage of acute cerebral infarction has obvious effect, high safety and high clinical value.