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血管性血友病因子(von Willebrand factor,vWF)是介导癌细胞与血小板结合以及癌血栓与内皮下组织粘附的重要“桥梁”。外周循环中的vWF主要来自内皮细胞,并形成分子量大小不等的多聚体。多聚体的大小是vWF与血小板和内皮下胶原结合能力的决定因素,多聚体的分子量越大,结合能力越强,血浆中vWF多聚体的大小主要受vWF裂解酶(vWF-
Von Willebrand factor (vWF) is an important “bridge” that mediates the binding of cancer cells to platelets and the adhesion of cancer thrombus to subendothelial tissue. The vWF in the peripheral circulation is mainly derived from endothelial cells and forms multimers of unequal molecular weight. The size of the multimers is a determinant of the binding capacity of vWF to platelets and subepithelial collagen. The larger the molecular weight of the polymer, the stronger the binding capacity. The size of the vWF multimer in plasma is mainly affected by the vWF-