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ＥＧＲ－１的启动子为早期生长反应因子－１基因上游约－５５０～０ｂｐ的一顺式作用元件，其活性受控于一些诱导剂，如电离辐射。联合ＥＧＲ－１的启动子与治疗基因（如ＴＮＦ－ａ、自杀基因），用辐射能在肿瘤局部从时、空调控治疗基因的表达，使其产物局限于肿瘤局部，并发挥放疗的杀肿瘤效应，而放疗与转基因产物又有协同作用。放射治疗与基因治疗的配伍为肿瘤的治疗提供了新思路。
The promoter of EGR-1 is a cis-acting element of about -550 ~ 0 bp upstream of the growth-response factor-1 gene and its activity is controlled by some inducers, such as ionizing radiation. The combination of EGR-1 promoter and therapeutic gene (such as TNF-a, suicide gene), the use of radioactive energy in the tumor local time and space-based regulation of gene expression, the product confined to tumor local and radiotherapy to play the tumor Effect, and radiation and genetically modified products have synergies. Radiation therapy and gene therapy compatibility for the treatment of cancer provides a new idea.