【摘 要】
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Fructose metabolism and fructose kinase KHK-C/A are key factors in the development of lipid oversynthesis-promoted metabolic disorders and cancer.Here,we summarize and discuss the current knowledge about the specific features of fructose metabolism and th
【机 构】
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Cancer Institute of The Affiliated Hospital of Qingdao University and Qingdao Cancer Institute,Qingd
论文部分内容阅读
Fructose metabolism and fructose kinase KHK-C/A are key factors in the development of lipid oversynthesis-promoted metabolic disorders and cancer.Here,we summarize and discuss the current knowledge about the specific features of fructose metabolism and the distinct roles of KHK C and KHK-A in metabolic liver diseases and their relevant metabolic disorders and cancer,and we highlight the specific protein kinase activity of KHK-A in tumor development.In addition,different approaches that have been used to inhibit KHK and the exploration of KHK inhibitors in clinical treatment are introduced.
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