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原发性肝癌(PHC)发病呈明显的家族聚集性,为进一步了解PHC的聚集规律和特征,探讨亲代遗传效应,本文分析了290个PHC家族的资料。结果表明:在肝癌家族史中,以母患肝癌为多见;尤其肝癌高发家族中45.28％先证者的母亲曾患肝癌,而且表明伴HBV感染的母患肝癌的先证者显著多于不伴HBV感染者(P<0.05)。显示了母患肝癌对子代的遗传效应远大于父患肝癌对子代的影响。可以认为有母患肝癌家族史,尤其伴HBV感染的肝癌家族成员罹患肝癌的风险更大,应对其加强随访,警惕PHC的发生。
The incidence of primary hepatocellular carcinoma (PHC) showed significant family aggregation. To further understand the aggregation patterns and characteristics of PHC and to explore the genetic effects of the parent, the data of 290 PHC families were analyzed. The results show that: in the family history of liver cancer, maternal cancer is more common; in particular, the mother of 45.28% of the probands of the high-family of hepatocellular carcinoma has suffered from hepatocellular carcinoma, and the proband of hepatocellular carcinoma with HBV infection is significantly more than With HBV infection (P <0.05). It is shown that the genetic effect of maternal HCC on the offspring is much greater than the effect of parental HCC on the offspring. It can be considered that there is a family history of maternal HCC, especially the HCC family members with HBV infection have a higher risk of liver cancer, and they should be followed up to guard against the occurrence of PHC.