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[目的]探讨乙型肝炎母亲血清HBVDNA含量及反映肝脏损伤的相关肝功能指标与新生儿HBV宫内感染的关系。[方法]连续收集2006年9月~2007年7月在太原市传染病医院产前检查及分娩的191例HBsAg阳性孕妇及其新生儿为研究对象,用荧光定量PCR(FQ-PCR)法检测母亲及其新生儿血清HBVDNA含量;用全自动生化仪检测肝功能;酶联免疫吸附试验(ELISA)检测新生儿血清HBsAg。采用SPSS13.0统计软件进行统计分析。[结果]孕妇血清HBVDNA含量与HBV宫内感染有关,且HBVDNA含量≥104copy/ml以上与宫内感染显著相关;乙肝母亲丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)水平与HBV宫内感染无关联。[结论]孕妇血清HBVDNA含量是HBV宫内感染的危险因素,且HBVDNA含量≥104copy/ml时,宫内感染发生率显著增加;乙肝母亲肝功能异常与HBV宫内感染无关。
[Objective] To investigate the relationship between serum HBVDNA level in hepatitis B mothers (HBV) and related liver function indexes and HBV intrauterine infection in neonates. [Methods] A total of 191 HBsAg positive pregnant women and their newborns were collected from prenatal examination and delivery in Taiyuan Infectious Disease Hospital from September 2006 to July 2007, and were detected by FQ-PCR HBVDNA content in serum of mothers and their newborns; liver function was detected by automatic biochemical analyzer; serum HBsAg of neonates was detected by enzyme-linked immunosorbent assay (ELISA). Using SPSS13.0 statistical software for statistical analysis. [Results] Serum HBVDNA levels in pregnant women were related to HBV intrauterine infection, and HBVDNA levels above 104 copies / ml were significantly associated with intrauterine infection. Hepatitis B mothers had a significant correlation with serum levels of alanine aminotransferase (ALT), aspartate aminotransferase ) Levels were not associated with HBV intrauterine infection. [Conclusion] The serum HBVDNA level in pregnant women is a risk factor for intrauterine infection of HBV, and the incidence of intrauterine infection is significantly increased when the HBVDNA level is above 104 copies / ml. The abnormal liver function of hepatitis B mothers has nothing to do with HBV intrauterine infection.