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目的:总结胃癌组织中rasP21和nm23基因表达联合检测与临床病理学因素及预后的关系.方法:60例福尔马林固定,石蜡包埋的胃癌切除标本,采用免疫组织化学方法(SP法)检测基因表达.结果:rasP21和nm23表达的分布根据肿瘤大体类型而不同,而且这些基因的表达方式与预后相关——nm23单独表达影响预后,而rasP21和nm23基因一定程度的联合表达可以延长生存期.结论:研究提示在rasP21和nm23基因之间有一种相互作用,分析两者的相互关系,将有助于判定胃癌患者的预后。
OBJECTIVE: To summarize the relationship between the expression of rasP21 and nm23 in gastric cancer and clinicopathological factors and prognosis.Methods: Sixty cases of gastric cancer with formalin fixed and paraffin-embedded were resected by immunohistochemistry (SP method) The expression of rasP21 and nm23 was different according to the general type of tumor, and the expression of these genes was correlated with the prognosis - the expression of nm23 alone affected the prognosis, while the combination of rasP21 and nm23 genes could prolong the survival .Conclusion: The research suggests that there is an interaction between rasP21 and nm23 genes and analyzing their correlation will help to determine the prognosis of patients with gastric cancer.