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目的 :探讨血清肌红蛋白 (Mb)、肌钙蛋白T(cTnT)和肌酸激酶同工酶 (CK -MB)对老年急性心肌梗死溶栓疗效早期的检测意义。方法 :应用酶联免疫分析法测定32例老年急性心肌梗死患者溶栓治疗后的测定Mb、cT nT、CK -MB浓度 ,分析老年急性心肌梗死患者溶栓再通组 (n=18)和溶栓未通组 (n=14)上述指标的变化情况。结果 :急性心肌梗死溶栓再通组Mb、cTnT和CK -MB达到峰值浓度的时间明显较未通组提前(P<0.05) ,其中 ,Mb较cTnT和CK -MB峰值出现更早 ,分别为 (7.4±2.5)h ,(13.7±4.1)h和 (14.4±2.7)h(P<0.01);Mb的诊断敏感性(79%)与诊断效率(87%)明显高于cTnT(60 %、75 %)和CK -MB(47 %、67 %)(P<0.01)。结论 :血清Mb、cTnT和CK -MB水平和变化情况可以较好地早期预测老年急性心肌梗死患者溶栓再通 ,其中Mb较cT nT及CK -MB具有更好的临床检测意义
Objective: To investigate the significance of serum myoglobin (Mb), troponin T (cTnT) and creatine kinase isoenzyme (CK-MB) in the early detection of thrombolytic therapy in elderly patients with acute myocardial infarction. Methods: The levels of Mb, cT nT, CK-MB in 32 elderly patients with acute myocardial infarction after thrombolysis were measured by enzyme-linked immunosorbent assay (ELISA), and the levels of Mb, cTnT and CK-MB in the elderly patients with acute myocardial infarction Plug the failed group (n = 14) changes in the above indicators. Results: The peak time of peak concentration of Mb, cTnT and CK-MB in acute thrombolysis recanalization group was significantly earlier than that of control group (P <0.05), Mb was earlier than that of cTnT and CK-MB, respectively (7.4 ± 2.5) h, (13.7 ± 4.1) h and (14.4 ± 2.7) h respectively (P <0.01). The diagnostic sensitivity and diagnostic efficiency of Mb were significantly higher than those of cTnT (79% 75%) and CK-MB (47%, 67%) (P <0.01). Conclusion: The levels and changes of serum Mb, cTnT and CK-MB can be used to predict thrombolytic recanalization in elderly patients with acute myocardial infarction. Mb has better clinical significance than cT nT and CK-MB