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中枢5-羟色胺能递质参与了下丘脑-垂体-肾上腺(HPA)轴系的功能调节。本研究观察了 Ketanserin(一种5-羟色胺-2受体的拮抗剂)对雄性大鼠的急性应激性血浆皮质酮反应的影响,验证5-羟色胺能递质是否参与了应激对下丘脑-垂体-肾上腺(HPA)轴系的激活作用。分别给动物两种不同剂量的 Ketanserin(2mg 及10mg/kg 体重),作用30分钟后,再进行10分钟的冷泳刺激,分别在冷泳刺激前、刺激中和刺激后20分钟处死动物,取动脉血,用放射免疫法
Central serotonergic neurotransmitters are involved in the functional regulation of the hypothalamic-pituitary-adrenal (HPA) axis. This study examined the effect of Ketanserin (an antagonist of serotonin-2 receptors) on the acutely responsive plasma corticosterone response in male rats to verify whether serotonergic neurotransmitters are involved in the stress response to the hypothalamus - Pituitary - adrenal (HPA) Axis Activation. Two different doses of Ketanserin (2mg and 10mg / kg body weight) were given to the animals respectively. After 30 minutes of action, cold water stimulation was performed for 10 minutes. Animals were sacrificed 20 minutes after stimulation and before stimulation Arterial blood, using radioimmunoassay