大骨节病是严重危害人民健康的地方病之一,在病因探索方面,虽有一百多年历史,学说纷云,但普遍趋向于本病是一种“水土病”。致病因子存在于水粮中。以往我们多次动物实验也证明用病区单纯水粮饲养动物至一定时期,在硫代谢和骨骼生长方面确实出现了不同于非病区水粮所饲养的动物、但是致病因子究竟存在于水中还是粮中,仍有些争论。有人认为,致病因子是通过病区水而致病的,改水能控制大骨节病的发生、发展,使发病率降 Kashin-Beck disease is one of the endemic diseases that seriously endanger the health of the people. Although there is a history of more than a hundred years in the exploration of etiology, there are many doctrines in the disease. However, the general trend is that this disease is a kind of “water and soil disease.” Pathogenic factors exist in water food. In the past we have repeatedly animal experiments also proved that the use of watertight water ration animals to a certain period of time, in the metabolism of sulfur and bone growth does appear different from non-ward water animals kept in the animal, but the pathogenic factor in the water actually exist Still in the grain, there is still some controversy. Some people think that the pathogenic factor is caused by the water ward disease, water change can control the occurrence and development of Kashin-Beck disease, the incidence decreased