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目的比较分析河南省开封市儿童医院就诊患儿和健康儿童麻疹抗体水平,为制定麻疹院内传播防控策略提供依据。方法采用酶联免疫吸附试验(ELISA)对开封市儿童医院0-4岁就诊患儿和健康儿童进行麻疹IgG抗体水平血清学检测,并进行流行病学分析。结果 812名0-4岁患儿麻疹抗体阳性率为48.28%,抗体几何平均浓度(GMC)为103.02 IU/L;其中517名0-7月龄患儿抗体阳性率和GMC分别为42.75%、86.99 IU/L;295名8月龄-4岁患儿抗体阳性率和GMC分别为57.97%、138.57 IU/L(χ~2=17.42,P<0.001;t=2.54,P=0.01)。165名8月龄-4岁健康儿童抗体阳性率和GMC分别为96.36%、920.71 IU/L,高于同年龄患儿(χ~2=76.95,P<0.001;t=8.62,P<0.001)。8月龄-4岁患儿含麻疹成分疫苗(MCV)接种率为78.64%,低于同年龄健康儿童的99.39%;接种过MCV的患儿或健康儿童抗体阳性率和GMC均高于未种患儿或健康儿童。结论开封市儿童医院就诊患儿麻疹抗体水平低,需研究综合性防控措施,提高患儿麻疹免疫水平,防止患儿的麻疹院内感染。
Objective To compare and analyze the level of measles antibody in children and healthy children in Kaifeng Children’s Hospital of Henan Province, and to provide the basis for formulating prevention and control strategies of measles in hospital. Methods Enzyme linked immunosorbent assay (ELISA) was used to detect the level of measles IgG antibodies in children aged 0-4 years and healthy children in Kaifeng Children’s Hospital, and the epidemiological analysis was performed. Results The positive rate of measles antibody in 812 children aged 0-4 years was 48.28% and the geometric mean antibody concentration was 103.02 IU / L. The positive rates of antibody and GMC in 517 children aged 0-7 months were 42.75% The positive rates of antibody and GMC in 295 children aged 8 months to 4 years were 57.97% and 138.57 IU / L, respectively (χ ~ 2 = 17.42, P <0.001; t = 2.54, P = 0.01). The positive rates of antibody and GMC in 165 healthy children aged from 8 months to 4 years were 96.36% and 920.71 IU / L respectively, higher than those in the same age group (χ ~ 2 = 76.95, P <0.001; t = 8.62, . The vaccination rate of measles-containing vaccine (MCV) in children aged 8 months to 4 years was 78.64%, which was lower than 99.39% of the healthy children of the same age. The positive rates of MCV and GMC in children vaccinated with MCV were higher than those without MCV Children or healthy children. Conclusion Children with measles in Kaifeng City Children’s Hospital treatment of measles antibody levels are low, the need to study comprehensive prevention and control measures to improve measles immunity in children with measles to prevent nosocomial infection in children.