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目的分析老年肺部感染患者万古霉素血药浓度的监测结果及相关PK/PD参数与临床疗效的关系。方法用荧光偏振免疫法,对万古霉素治疗肺部感染的患者70例进行血药浓度测定,并对相关PK/PD参数进行统计学分析。结果万古霉素的峰、谷浓度均在治疗窗范围内的仅占40%左右;万古霉素的Cmax与疗效有关联,Cmax越高疗效较好;万古霉素的临床疗效可能与AUC/MIC和Cmax/MIC等PK/PD参数相关。结论老年感染患者使用万古霉素个体差异大,应加强血药浓度监测。
Objective To analyze the monitoring results of vancomycin blood concentration in elderly patients with pulmonary infection and the relationship between PK / PD parameters and clinical efficacy. Methods Fluorescence polarization immunoassay was used to determine the serum concentration of vancomycin in 70 patients with lung infection. The PK / PD parameters were analyzed statistically. Results The peak and valley concentrations of vancomycin were only about 40% within the therapeutic window. The Cmax of vancomycin was correlated with the curative effect. The higher the Cmax was, the better the curative effect was. The clinical efficacy of vancomycin may be related to the AUC / MIC Related to PK / PD parameters such as Cmax / MIC. Conclusion Vancomycin in elderly patients with significant differences in individual should strengthen blood drug concentration monitoring.