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目的:探讨检测凝血四项指标,以分析各型乙肝患者凝血功能状况及对预后判断的价值。方法:用血凝仪分组检测凝血酶原时间(PT)、部分活化凝血活酶时间(APTT)、凝血酶时间(TT)及纤维蛋白原(Fbg)含量并进行统计学比较分析。结果:与对照组相比慢肝重度组、急肝重度组、肝硬化组PT、APTT、TT三项指标的均值均不同程度延长,Fbg降低(P<0.01),有统计学差异(P<0.05),其中慢肝重度和肝硬化患者Fbg含量的异常率明显高于其他二项指(P<0.01或0.05)。结论:检测凝血四项功能可以从多个角度更客观、准确地反映严重肝损害的肝炎患者凝血功能状况及其预后。
Objective: To investigate the four indicators of coagulation test to analyze the coagulation status and the prognostic value of each type of hepatitis B patients. Methods: The prothrombin time (PT), partial activated thromboplastin time (APTT), thrombin time (TT) and fibrinogen (Fbg) content were determined by coagulometer group and compared statistically. Results: Compared with the control group, the average of PT, APTT and TT in chronic severe hepatitis group, severe acute liver disease group and cirrhosis group were all prolonged to different extents, Fbg decreased (P <0.01), with statistical significance (P < 0.05). The abnormal rate of Fbg in patients with chronic liver disease and cirrhosis was significantly higher than those in other two items (P <0.01 or 0.05). Conclusion: The detection of four functions of coagulation can more objectively and accurately reflect the coagulation status and prognosis of patients with severe liver damage from multiple perspectives.