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可乐定(Clonidine)是咪唑啉类肾上腺素能α-受体激动剂,具有多种药理作用。近年来许多学者对其镇痛机制进行了研究。可乐定在多种镇痛实验模型均呈现镇痛效应,在有些模型镇痛其作用甚至强于吗啡。鉴于可乐定镇痛机制完全不同于阿片类药物,故对其镇痛机制研究有一定的理论意义。 可乐定镇痛作用部位 可乐定同类物ST91[2-(2,6—二氯氨基苯)—2—咪唑啉]为低脂溶性不易透过血脑屏障的药物,外周给药产生可
Clonidine is an imidazoline adrenergic alpha-agonist with a variety of pharmacological actions. In recent years, many scholars studied its analgesic mechanism. Clonidine showed analgesic effects in a variety of analgesic experimental models, and in some models analgesic even stronger than morphine. In view of clonidine analgesic mechanism is completely different from opioids, so its analgesic mechanism has some theoretical significance. Clonidine analgesic site of the same kind of substance clonidine ST91 [2- (2,6-dichloroaminophenyl) -2-imidazoline] low fat-soluble drugs difficult to penetrate the blood-brain barrier, peripheral administration can produce