对１６例（次）使用激素治疗和１２例尚未用激素治疗的小儿肾病综合征患者进行了ＡＣＴＨ试验。在ＡＣＴＨ静脉滴注前后分别测定血浆皮质醇浓度，结果显示治疗组与对照组的皮质醇浓度无论ＡＣＴＨ滴注前后差异均有高度显著性，治疗组明显减低。提示激素治疗后肾上腺皮质功能有不同程度减低，且对ＡＣＴＨ刺激的反应性亦降低。运用ＡＣＴＨ试验能较好的反映肾上腺皮质的储备功能和垂体－肾上腺轴的调节功能。重复试验还可判断疾病的预后与转归。 ACTH tests were performed on 16 patients (twice) with hormone therapy and 12 children with nephrotic syndrome who had not yet been treated with hormone therapy. Before and after ACTH intravenous infusion of plasma cortisol concentrations were measured, the results showed that the treatment group and control group cortisol concentrations regardless of ACTH infusion before and after the differences were highly significant, the treatment group was significantly reduced. Prompts after adrenal corticosteroid treatment have varying degrees of reduction, and the response to ACTH stimulation is also reduced. The use of ACTH test can better reflect the reserve function of the adrenal cortex and the regulation function of the pituitary - adrenal axis. Repeated trials can also determine the prognosis and outcome of the disease.