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目的 了解宝鸡市近年来第一类疫苗不良反应发生情况.方法 分析宝鸡市2004-2016年GAVI项目免疫规划信息管理系统第一类疫苗有关的疑似预防接种异常反应个案信息.结果 2004-2016年宝鸡共报告第一类疫苗不良反应个案897例, 报告发生率为9.77/10万, 其中一般反应701例 (78.15％), 异常反应196例 (21.85％).报告例数居前3位的疫苗分别为无细胞百白破疫苗 (285例, 31.77％), 儿童白破疫苗 (163例, 18.17％) 和A群流脑疫苗 (89例, 9.92％).异常反应临床诊断居前3位的分别为过敏性皮疹 (159例, 81.12％), 无菌性脓肿 (13例, 6.63％) 和血管性水肿 (7例, 3.57％).结论 儿童疫苗不良反应以无细胞百白破为主, 异常反应主要是过敏性皮疹.“,”Objective To investigate the occurrence of adverse reactions of the first class of vaccines in recent years in Baoji City. Methods The individual case information of suspected abnormal reaction in preventive vaccination related to the first class of vaccines from information management system of planned immunization of GAVI project in Baoji City in 2004-2016 were analyzed. Results A total of 897 individual cases of adverse reactions of the first class of vaccines were reported and the reported rate was 9. 77/100 000, among which 701 were of general reaction (78. 15％) and 196 were of abnormal reaction (21. 85％).Vaccines with the first three reported cases were APDT (285 cases, 31. 77％), TD (163 cases, 18. 17％) and A-MCV (89 cases, 9. 92％). The top 3 clinical diagnosis of abnormal reaction were anaphylactic rash (159 cases, 81. 12％), sterile abscess (13 cases, 6. 63％) and angioedema (7 cases, 3. 57％). Conclusion The main adverse reaction of childhood vaccinations is APDT and the major abnormal reaction is anaphylactic rash.