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本文首先对国外 Genelabs和 Yes两种抗-HEVIgM与抗-HEVIgG ELISA试剂盒比较的基础上,通过对急性病毒性肝炎病人、一般健康人群和特殊人群共 816名进行HEVIgM和 HEVIgG两种抗体测定和部分对象抗-HEVIgM消长情况分析,提出今后戊型肝炎诊断上必须要用抗-HEVIgM标记物作为诊断依据,以取代单一测定抗-HEVIgG的情况;同时还证实了存在着 HEV亚临床型感染和隐性感染的事实,今后拟将抗-HEVIgM作为流行病学调查的有力检测手段,并希望加速研制国产抗-HEV试剂。
Based on the comparison of two anti-HEVIgM anti-HEVIgG ELISA kits between Genelabs and Yes in foreign countries, 816 HEV IgM and HEVIgG antibodies were tested in 816 patients with acute viral hepatitis, general healthy people and special people HEVIgM growth and decline in some subjects analysis, proposed in the future diagnosis of hepatitis E must use anti-HEVIgM marker as a diagnostic basis to replace a single determination of anti-HEVIgG situation; also confirmed the existence of sub-clinical infection with HEV and In the future, it is proposed to use anti-HEVIgM as a powerful means of epidemiological investigation and to accelerate the development of domestic anti-HEV reagents.