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目的探讨孕妇血清胱抑素C(Cys C)、尿素氮(BUN)和肌酐(Cr)与妊娠期高血压疾病的关系。方法用日立7180全自动生化分析仪对50例妊娠期高血压疾病孕妇及50例妊娠中晚期正常孕妇进行血清Cys C、BUN、Cr的检测。结果重度及轻度子痫前期组Cys C值明显高于正常孕妇组(P<0.01),且有显著性差异,重度子痫前期组Cys C明显高于轻度子痫前期组,有显著性差异(P<0.05);而重度子痫前期组BUN、Cr明显高于正常孕妇组(P<0.01),有显著性差异,但轻度子痫前期组BUN、Cr与正常孕妇组相比,无显著性差异(P>0.05)。结论血清Cys C的检测对于妊娠期高血压疾病的肾功能损害具有较好的诊断价值,联合检测血清Cys C、BUN、Cr有利于HDCP及其并发的肾功能损害的诊断及监测。
Objective To investigate the relationship between serum cystatin C (Cys C), blood urea nitrogen (BUN) and creatinine (Cr) in pregnant women and gestational hypertension. Methods Serum levels of Cys C, BUN and Cr were detected in 50 pregnant women with gestational hypertension and 50 normal pregnant women in the second trimester of pregnancy by using Hitachi 7180 automatic biochemical analyzer. Results The levels of Cys C in severe preeclampsia and mild preeclampsia were significantly higher than those in normal preeclampsia (P <0.01), and there was a significant difference. The levels of Cys C in severe preeclampsia were significantly higher than those in mild preeclampsia (P <0.05). However, the levels of BUN and Cr in severe preeclampsia group were significantly higher than those in normal pregnant women (P <0.01), but the levels of BUN and Cr in mild preeclampsia group were significantly lower than those in normal pregnant women No significant difference (P> 0.05). Conclusion The detection of serum Cys C has a good diagnostic value for renal dysfunction in hypertensive disorders of pregnancy. Combined detection of serum Cys C, BUN and Cr is helpful for the diagnosis and monitoring of HDCP and its concurrent renal impairment.