2型糖尿病(T2DM)是遗传异质性疾病,从遗传模式上讲可分为单基因遗传性糖尿病和多基因遗传性糖尿病。前者往往由一个作用较强的基因突变导致,发病较早,呈现孟德尔遗传模式;后者由多个作用较弱的基因再加上环境因素共同导致疾病的发生。在T2DM中,由于基因诊断技术还不能广泛应用,加上其早期治疗不依赖胰岛素,所以临床上这些 Type 2 diabetes mellitus (T2DM) is a hereditary heterogeneous disease that can be classified into monogenic hereditary diabetes and polygenic hereditary diabetes. The former is often caused by a strong role in gene mutations, the incidence of earlier Mendelian genetic model; the latter by a number of weaker genes plus environmental factors together lead to the occurrence of the disease. In T2DM, genetic diagnostic techniques are not yet widely available, and their early treatment is not dependent on insulin, so clinically these