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目的:研究细胞色素P4502C19(CYP2C19)基因多态性与结直肠癌发生的关系。方法:对117例结直肠癌患者和109名对照人群进行病例对照研究,采用PCR-RFLP方法检测CYP2C19基因型。结果:纯合子强代谢型(homEM)、杂合子强代谢型(hetEM)和弱代谢型(PM)分布频度在结肠癌组(38.7%、45.2%和16.1%)、直肠癌组(34.5%、52.7%和12.7%)和对照组(36.7%、44.0%和19.3%)间差异无统计学意义,P>0.05;在结肠癌和直肠癌组,PM型经性别和年龄调整后的OR值分别为0.693(95%CI:0.266～1.807,P=0.454)和0.757(95%CI:0.263～2.184,P=0.607),差异无统计学意义。结论:CYP2C19基因多态性与结直肠癌发生的危险性无直接关系。
Objective: To study the relationship between the polymorphism of cytochrome P4502C19 (CYP2C19) and the occurrence of colorectal cancer. Methods: A case-control study was performed in 117 patients with colorectal cancer and 109 control subjects. CYP2C19 genotypes were detected by PCR-RFLP. Results: The frequencies of homome, hetEM and PM in homozygous group were significantly higher than those in colon cancer group (38.7%, 45.2% and 16.1%), rectal cancer group (34.5% , 52.7% and 12.7% respectively) and the control group (36.7%, 44.0% and 19.3%, P> 0.05). In colorectal cancer and rectal cancer group, the gender and age-adjusted odds ratio (95% CI: 0.266-1.807, P = 0.454) and 0.757 (95% CI: 0.263-2.184, P = 0.607, respectively), the difference was not statistically significant. Conclusion: CYP2C19 gene polymorphism is not directly related to the risk of colorectal cancer.