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目的了解医院临床分离多重耐药菌分布及细菌耐药情况,为多重耐药菌医院感染防控提供科学依据。方法通过回顾性分析的方法,对某医院住院患者送检标本多重耐药菌检出情况及细菌药敏试验结果进行统计分析。结果该医院在2015年度共检出多重耐药菌990株,产超广谱β内酰胺酶阳性大肠埃希菌检出最多。多重耐药菌主要分布在重症监护病房(ICU)、神经外科和神经内科,多重耐药菌分离自痰标本和尿液标本分别占49.8%和21.5%。临床分离的革兰阴性菌对哌拉西林/他唑巴坦、阿米卡星、美洛培南敏感,但对多数临床常用抗菌药物普遍耐药。结论该医院多重耐药菌感染形势严峻,应加强抗菌药物合理使用与监测,强化手卫生措施。
Objective To understand the distribution of multidrug-resistant bacteria in clinical isolates and bacterial resistance in hospitals, and to provide a scientific basis for the prevention and control of multi-resistant bacterial nosocomial infections. Methods By means of retrospective analysis, the detection of multiple drug-resistant bacteria in hospital inpatients and the results of bacterial susceptibility test were statistically analyzed. Results The hospital detected a total of 990 multidrug-resistant bacteria in 2015, and the most detectable ESBLs-producing Escherichia coli was detected. Multidrug-resistant bacteria were mainly distributed in intensive care unit (ICU), neurosurgery and neurology, and sputum samples and urine samples from multiple drug-resistant bacteria accounted for 49.8% and 21.5% respectively. Gram-negative bacteria clinically isolated are sensitive to piperacillin / tazobactam, amikacin, and meropenem, but are generally resistant to most clinically used antimicrobials. Conclusion The situation of multi-drug resistant bacteria infection in this hospital is severe. Reasonable use and monitoring of antimicrobial agents should be strengthened and hand hygiene measures should be strengthened.