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临床上应用的中药注射剂有上百种,但其对细胞色素P450 2C9酶活性的研究却很少。中药注射剂对CYP2C9酶的活性不管是抑制或是诱导作用,在应用经CYP2C9代谢的药物时,要重视中药注射剂对其的影响,可能会产生代谢性药物相互作用,为避免药物不良反应发生率增加、药物疗效降低,中药注射剂对CYP2C9酶活性的影响研究值得关注。本文将中药注射剂对CYP2C9酶的活性影响的研究进行了总结和分析,了解中药注射剂对CYP2C9酶活性的影响的研究现状。
There are hundreds of traditional Chinese medicine injections for clinical use, but few studies have investigated the activity of cytochrome P450 2C9. Traditional Chinese medicine injection of CYP2C9 enzyme activity either inhibition or induction, the application of CYP2C9 metabolism of drugs, we should pay attention to the impact of traditional Chinese medicine injections, may produce metabolic drug interactions, in order to avoid the incidence of adverse drug reactions increased , The curative effect of medicine is reduced, and the research on the effect of Chinese medicine injection on CYP2C9 enzyme activity deserves our attention. This article summarizes and analyzes the research on the effects of Chinese traditional medicine injection on the activity of CYP2C9 enzyme, and studies the influence of Chinese medicine injection on the activity of CYP2C9 enzyme.