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当代治疗心力衰竭(以下简称心衰)的一个重要研究课题是探索最适宜的血管扩张剂与β-受体兴奋剂联合应用,以克服其不利作用,而使有益效应发挥到最大限度。自从70年代初期血管扩张剂应用于心衰治疗以来,血管扩张剂与β-受体兴奋剂联合应用,国外进行了许多研究,国内也有应用酚妥拉明和多巴胺静点治疗急性心衰伴血压明显降低甚至休克的病人,取得了满意疗效。有人预计今后将发现更有效的药物,其中,对血管平滑肌有特异作用的前列腺素(PGE),可能是有前途的血管扩张剂。作者于1981年12月应用白求恩医科大学药物研究室制前列腺素E_1(PGE_1)与多巴胺联合应用对两例心肌梗塞合并心衰伴低血压休克得到了满意的治疗效果,报告如下:
An important research topic in the contemporary treatment of heart failure (hereinafter referred to as heart failure) is to explore the most suitable vasodilator and β-receptor agonist in combination to overcome its adverse effects, so that the beneficial effects to their maximum. Vasodilators and β-receptor agonists have been used since the early 1970s when vasodilators were used in the treatment of heart failure. Many researches have been done abroad. There are also some domestic applications of intravenous injection of phentolamine and dopamine to treat acute heart failure with obvious blood pressure Reduce or even shock patients, and achieved satisfactory results. It is expected that more effective drugs will be found in the future, of which prostaglandin (PGE), which has a specific effect on vascular smooth muscle, may be a promising vasodilator. The author in December 1981 Bethune Medical University Pharmaceutical Research Department prostaglandin E_1 (PGE_1) and dopamine combined application of two cases of myocardial infarction with heart failure and hypotension were treated with satisfactory results, the report is as follows: