【摘 要】
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OPA-interacting protein 5 antisense transcript 1 (OIP5-AS1) plays an important regulatory role in various types of cancers.However,the functional role and regul
【机 构】
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Department of General Surgery, Nanhua Hospital Affiliated to Nanhua University, Hengyang 421002, Chi
论文部分内容阅读
OPA-interacting protein 5 antisense transcript 1 (OIP5-AS1) plays an important regulatory role in various types of cancers.However,the functional role and regulatory mechanisms of OIP5-AS1 in gastric cancer (GC) remain largely unknown.In this study,we found that the expression of OIP5-AS1 was increased in GC tissues compared with that in adjacent non-cancerous tissues,which was significantly associated with shorter overall survival time of patients.In addition,OIP5-AS1 expression was also increased in GC cell lines including NCI-N87,MKN-45,BGC-823 and SGC-7901,when compared with that in normal gastric epithelial cell line GES-1.Knockdown of OIP5-AS1 markedly suppressed the proliferation and colony formation activities of GC cells,induced G0/G1 arrest and apoptosis of GC cells in vitro,and restrained tumor growth in vivo.Mechanistically,OIP5-AS1 functions as an oncogenic competing endogenous RNA by binding to and sequestering miR-422a to elevate the expression of anoctamin-1.Our study first demonstrated that OIP5-AS1 is a critical and powerful regulator of GC pathogenesis and may represent a novel candidate target for GC therapy.
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