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PI3激酶家族包括 3种类型 ,Ⅰ型和Ⅲ型的催化亚基与调节亚基形成异二聚体 ,II型不形成异二聚体 ,具有独特的C2结构域。生长因子、有丝分裂原等多种因素可使其活化。所生成的 3 磷酸肌醇脂 (PIP、PIP2、PIP3)具有第二信使功能 ,即作为信号转导分子膜易位活化的“锚”分子。PI3 K家族在细胞的增殖、抗凋亡、细胞迁移、膜泡转运、细胞癌性转化等众多过程有关的信号转导方面起重要作用 ,本文就此予以综述。
The PI3 kinase family includes three types, type I and type III catalytic subunits that form heterodimers with regulatory subunits, type II do not form heterodimers, and possess unique C2 domains. Growth factors, mitogen and other factors can make it activated. The resulting phosphoinositide 3 phosphatidylinositol (PIP, PIP2, PIP3) has a second messenger function as an “anchor” molecule that activates the translocation of signal transduction molecules. The PI3K family plays an important role in signal transduction associated with many processes such as cell proliferation, anti-apoptosis, cell migration, vesicle trafficking, and cellular cancerous transformation. This article reviews this.