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1969年到1990年California San Francisco大学进行了353例多胎妊娠的产前检测。在此期间做了22948次羊膜穿刺术。多胎妊娠发生率是1/65次妊娠,其中除14例是先天畸形、发育迟缓、双胎输血或者当穿刺时双胎之一已经死亡外,着重回顾分析了其余339例羊膜穿刺多胎妊娠的情况。该中心指出在常规使用超声检查联合穿刺术之前常常没有发现多胎妊娠。双胎和单胎妊娠相比,与母亲年龄和医生进行羊膜穿刺的经验无区别。此外对于妊娠并发胎儿死亡的和没有死亡的相比也无区别。在339例进行羊膜穿刺的多胎妊娠中,有330例双胎,9例三胎妊娠。三对夫妇用双胎妊娠中的一个胎儿核型异常就选择了中止妊娠。在336例继续妊娠中,12例双胎于妊娠25周前自然流产,胎儿丢失率为3.57％。而单胎妊娠的胎儿死亡率是0.60％(P<0.001)。有一例系一个双胎中之一个胎儿在羊膜穿刺之后死亡,但妊娠仍继续。围产期死亡率(PMR)在多胎妊娠组中包括六个死胎和两个新
Prenatal testing of 353 multiple pregnancies was conducted at the University of California San Francisco from 1969 to 1990. During this period 22948 amniocentesis was done. The incidence of multiple pregnancies was 1/65 pregnancy, with the exception of 14 cases of congenital malformations, stunting, twins transfusions or death of one of the twins while puncturing, and the remaining 339 cases of amniocentesis were analyzed retrospectively . The center states that multiple pregnancies are often not found before routine use of ultrasound for combined puncture. Twin and singleton pregnancies compared with the mother’s age and doctor’s experience of amniocentesis no difference. In addition, there is no difference between the fetus with and without fetal death in pregnancy. In 339 cases of multiple pregnancy with amniocentesis, there were 330 twins and nine third pregnancies. Three couples chose to discontinue pregnancy with an abnormal fetal karyotype in twin pregnancies. Of the 336 consecutive pregnancies, 12 had spontaneous abortion 25 weeks before gestation, with a fetal loss of 3.57%. The singleton pregnancy fetal mortality rate was 0.60% (P <0.001). In one case, one of the twins died after amniocentesis, but pregnancy continued. Perinatal mortality (PMR) included six stillbirths and two newborns in the multiple pregnancy group