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目的 探讨影响胚胎冷冻结果及冻融胚胎移植后妊娠结局的因素。方法 用常规IVF -ET方法对 2 2例患者进行 2 4个周期的冻融胚胎移植 ,并对结果进行统计学分析。结果 2 2例患者 2 4个周期中平均每周期冷冻胚胎 5个 ,解冻后 ,每周期平均存活 4个 ,继续卵裂 3个 ,平均存活率为 83 3% ,继续卵裂率为 84 %。冷冻前、解冻后、移植胚胎 3组的胚胎平均评分分别为 8 2 ,8,7 5 ,组间无统计学差异 (P >0 0 5 ) ;移植后临床妊娠率达 2 2 7% ,每个取卵周期的临床妊娠率由 2 8 9%提高至 31 7% ;患者年龄、胚胎质量、子宫内膜状态与胚胎着床率密切相关。结论 :胚胎冷冻技术是对人类辅助生殖技术体系的重要补充和完善 ,成功的关键在于胚胎质量、适宜的冷冻程序、内分泌环境及子宫内膜发育与胚胎发育的同步化
Objective To investigate the factors affecting the outcome of embryo freezing and the outcome of pregnancy after frozen-thawed embryo transfer. Methods Twenty-two patients underwent routine 4-cycle freeze-thaw embryo transfer with routine IVF-ET and the results were statistically analyzed. Results In 2 24 patients, 5 embryos per cycle were averagely frozen. After thawing, the average number of embryos survived per cycle was 4 and the number of cleavage was 3. The average survival rate was 83 3% and the rate of continued cleavage was 84%. After freezing, thawed, the average embryo scores of the three groups were 82, 8 and 75 respectively, with no significant difference between the two groups (P> 0.05). The clinical pregnancy rate after transplantation was 27.7% The clinical pregnancy rate of one oocyte retrieval cycle increased from 29.9% to 31.7%. The patient’s age, embryo quality and endometrium status were closely related to the embryo implantation rate. Conclusion: Embryo freezing technology is an important supplement and perfection to human assisted reproductive technology system. The key to success lies in embryo quality, suitable freezing procedure, endocrine environment and synchronization of endometrial development and embryo development