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目的比较紫杉醇脂质体与普通紫杉醇治疗老年非小细胞肺癌的疗效及毒副反应。方法 68例老年非小细胞肺癌患者随机分为试验组和对照组。试验组33例给予紫杉醇脂质体135mg/m2,对照组35例给予紫杉醇135mg/m2,每21天为一周期,共2周期。观察两组的疗效及毒副反应情况。结果两组在疗效及血液学毒性、消化道反应的差异无统计学意义,但因溶媒产生的过敏反应方面,试验组明显低于对照组,有统计学意义。结论紫杉醇脂质体治疗老年非小细胞肺癌效果良好,两种紫杉醇疗效相当,但紫杉醇脂质体的过敏反应明显低于紫杉醇。
Objective To compare the efficacy and side effects of paclitaxel liposomes and paclitaxel in the treatment of elderly non-small cell lung cancer. Methods 68 cases of elderly patients with non-small cell lung cancer were randomly divided into experimental group and control group. 33 cases of experimental group were given paclitaxel liposome 135mg / m2, 35 cases of control group was given paclitaxel 135mg / m2, every 21 days for a cycle, a total of 2 cycles. The curative effect and side effect of the two groups were observed. Results There was no significant difference in curative effect, hematological toxicity and digestive tract reaction between the two groups. However, the experimental group was significantly lower than the control group in terms of the allergic reaction caused by the vehicle, which was statistically significant. Conclusion paclitaxel liposomes are effective in the treatment of elderly non-small cell lung cancer. The efficacy of the two paclitaxel is equivalent, but the allergic reaction of paclitaxel liposome is obviously lower than paclitaxel.