近年来革兰氏阴性杆菌感染,尤其是医院内感染,已成为一个严重问题．我们常应用氨基甙类抗菌素治疗这些严重感染患者,特别是全身衰弱及免疫功能受抑制的病人。各种氨基甙类抗菌素的药理作用相同,杀菌机理也相似:但抗菌活力及毒性作用则有差异,即对某一种或一株细菌;一种氨基甙抗菌素可能比另一种抗菌活力为强;药物的毒性亦有大小 In recent years, Gram-negative bacilli infections, especially nosocomial infections, have become a serious problem. We often use aminoglycoside antibiotics to treat these severely infected patients, especially those with weakened body and suppressed immune function. The pharmacological effects of various aminoglycoside antibiotics are the same, and the bactericidal mechanism is similar: but the antibacterial activity and toxicity are different, that is, for one kind or one strain of bacteria; one kind of aminoglycoside antibiotic may be stronger than the other kind of antibacterial activity The toxicity of drugs also has size