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目的:制备桂利嗪-β-环糊精包合物,并对包合物含量、溶解度进行了测定。方法:采用饱和溶液法制备桂利嗪-β-环糊精包合物。结果:经紫外光谱、相溶解度图法鉴定,桂利嗪与β-环糊精确已形成包合物,β-环糊精对桂利嗪的增溶倍数为3.33。结论:桂利嗪-β-环糊精包合物可使桂利嗪溶解度增加。
Objective: To prepare the inclusion compound of cinnarizine-β-cyclodextrin, and to determine the content of inclusion compound and its solubility. Methods: Cinnarizine-β-cyclodextrin inclusion complex was prepared by saturated solution. Results: It was identified by UV spectrophotometry and phase solubility diagram that the combination of cinnarizine and β-cyclodextrin did form an inclusion complex. The solubilization ratio of β-cyclodextrin to cinnarizine was 3.33. Conclusion: Cinnarizine-β-cyclodextrin inclusion complex can increase the solubility of cinnarizine.