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中药方剂可以影响骨髓间充质干细胞的骨向分化能力,目前此方面的研究主要是对中药复方和具有补肾作用的单味中药以及中药有效成分或部位进行的药理研究。基于对该领域研究现状的归纳与分析,提出了研究影响骨髓间充质干细胞骨向分化能力的方药选择思路和实验研究思路,分别是:注重对补肾方药具有协同作用中药的研究、开展中药有效成分或组分配伍的研究、加强促进MSCs骨向分化方药筛选与对比研究、体内体外结合机制探讨的研究。
Traditional Chinese medicine prescription can affect the bone differentiation ability of bone marrow mesenchymal stem cells. At present, the research in this aspect mainly focuses on the pharmacological research on traditional Chinese medicine compound, single Chinese medicine with kidney-tonifying effect and active ingredients or parts of traditional Chinese medicine. Based on the summarization and analysis of the research status in this field, this paper put forward the research ideas and experimental research ideas of prescriptions that affect the bone differentiation ability of MSCs, which are as follows: Pay attention to the study of traditional Chinese medicine Component or component compatibility research, strengthen the promotion of bone marrow-derived MSCs differentiation of drug screening and comparative study of in vitro and in vivo binding mechanism.