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目的探讨N端脑钠肽前体(NT-proBNP)与心力衰竭患者心功能NYHA分级及左室射血分数(LVEF)的关系,研究NT-proBNP对心力衰竭患者的诊断及预后的临床价值。方法选取106例心力衰竭患者,心功能情况按照纽约心脏病协会(NYHA)分级,采用电化学发光法测定NT-proBNP的含量,心脏彩色多普勒超声测定左室结构和左室射血分数,研究NT-proBNP的变化与心功能NYHA分级及左室射血分数和预后的关系。结果 NT-proBNP水平与LVEF值之间呈负相关(r=-0.736,P<0.05),随着NYHA心功能分级的增加,患者的NT-proBNP含量升高,各组间比较具有显著性差异(P<0.05),动态监测NT-proBNP发现,治疗“有效”组的心衰患者NT-proBNP水平与治疗前比降低,而心衰“死亡”组患者在治疗后的NT-proBNP水平较治疗前基线下降少,甚至升高。结论 NT-proBNP能够反映心功能的状态,它对心力衰竭患者的诊断、治疗监测及预后的评估具有重要意义。
Objective To investigate the relationship between N-terminal pro-brain natriuretic peptide (NT-proBNP) and NYHA classification and left ventricular ejection fraction (LVEF) in patients with heart failure and to investigate the clinical value of NT-proBNP in the diagnosis and prognosis of patients with heart failure. Methods Sixty-six patients with heart failure were selected. The cardiac function was graded according to New York Heart Association (NYHA), the content of NT-proBNP was determined by electrochemiluminescence, the left ventricular ejection fraction and left ventricular ejection fraction were measured by color Doppler sonography, To investigate the relationship between the changes of NT-proBNP and cardiac function NYHA classification and left ventricular ejection fraction and prognosis. Results The level of NT-proBNP was negatively correlated with LVEF (r = -0.736, P <0.05). With the increase of NYHA functional class, the NT-proBNP level in patients increased significantly, with significant difference between the groups (P <0.05). The dynamic monitoring of NT-proBNP found that the NT-proBNP level in patients treated with “effective” group was significantly lower than that before treatment, while the patients with heart failure “” death " ProBNP levels decreased less than baseline before treatment, and even increased. Conclusion NT-proBNP can reflect the status of cardiac function, which is of great significance for the diagnosis, treatment monitoring and prognosis evaluation of patients with heart failure.