秋水仙硷能抑制四氯化碳引起的大鼠的肝纤维化并改善其肝功能。在临床上,秋水仙硷也能改善严重肝硬化患者的病情。本文报告用秋水仙硷(每周5日,每日1毫克)或安慰剂(葡萄糖)治疗28例门诊病人24个月的双盲随机试验结果。28例按相似的年龄、性别、患病时间长短以及酒精中毒发生率(50％)等随机分为两组。每月作体检及肝功能检查;每6个月作肝活险1次,用双盲法检查,并以1～4+分级(炎症和纤维化)。全部病例的胆红素均低于1毫克％,凝血酶原低于16/12,试验前均经组织学 Colchicine inhibits carbon tetrachloride-induced hepatic fibrosis and improves liver function in rats. Clinically, colchicine can also improve the condition of patients with severe cirrhosis. This article reports a 24-month, double-blind, randomized trial of 28 colorectal patients treated with colchicine (5 mg daily, 1 mg daily) or placebo (glucose). 28 cases were randomly divided into two groups according to similar age, gender, duration of illness and the incidence of alcoholism (50%). Every month for physical examination and liver function tests; every 6 months for liver risk 1, double-blind examination, and 1 ~ 4 + classification (inflammation and fibrosis). All cases of bilirubin were less than 1 mg%, prothrombin less than 16/12, before the test by histology