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目的确定胰头癌和壶腹癌在导致胆管梗阻方面是否存在差异。方法分析患者住院后内镜逆行胰胆管造影之前的肝功检测指标与梗阻近段胆管直径的相关性。结果胰头癌组血清丙氨酸转移酶和总胆红素水平高于壶腹癌组(P<0.05,P<0.01),壶腹癌组梗阻近段胆管扩张程度较胰头癌组明显(P<0.001)。胰头癌组梗阻近段胆管直径与血清总胆红素之间存在明显相关性(P<0.001),壶腹癌组两者之间无相关性(P>0.05)。结论胰头癌与壶腹癌导致的胆管梗阻之间存在差异,壶腹癌组不存在黄疸越重胆管扩张越明显的特点。
Objective To determine whether there is a difference in the incidence of biliary obstruction between pancreatic cancer and ampullary carcinoma. Methods The correlation between the indexes of liver function before endoscopic retrograde cholangiopancreatography and proximal bile duct diameter was analyzed after the hospitalization. Results Serum levels of alanine aminotransferase and total bilirubin in pancreatic head cancer group were significantly higher than those in ampullary carcinoma group (P <0.05, P <0.01). The extent of obstruction in ampulla carcinoma group was significantly higher than that in pancreatic carcinoma group P <0.001). There was a significant correlation between the size of bile duct obstruction and serum total bilirubin (P <0.001) in pancreatic head cancer group and no correlation between ampulla carcinoma group and control group (P> 0.05). Conclusions There are differences between bile duct obstruction caused by pancreatic cancer and ampullary carcinoma. There is no obvious characteristic of more bile duct dilation in jugular carcinoma group.