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目的观察胃癌组织中骨髓相关蛋白-14(S100A9)的表达变化,探讨其与胃癌患者临床病理特征的关系。方法选择手术切除的胃癌组织标本82份为胃癌组,选择癌旁正常组织标本82份为对照组。采用免疫组织化学SP法,检测两组S100A9蛋白的表达,分析S100A9蛋白阳性与胃癌患者性别、年龄、肿瘤浸润深度、分化程度、淋巴结转移、病理分期、肿瘤直径等临床病理特征的关系。结果胃癌组S100A9蛋白表达阳性率为59.8%(49/82),对照组为6.1%(5/82),胃癌组S100A9的表达阳性率高于对照组(P<0.05)。胃癌患者T3+T4期者S100A9蛋白的表达高于T1+T2期者,低分化者S100A9蛋白的表达高于高、中分化者,存在淋巴结转移者S100A9蛋白的表达高于无淋巴结转移者,病理分期Ⅲ+Ⅳ期者S100A9蛋白的表达高于Ⅰ+Ⅱ期者(P均<0.05)。结论胃癌组织中S100A9蛋白的表达明显上调,且与淋巴结转移、肿瘤浸润深度、临床分期、分化有关。
Objective To investigate the expression of bone marrow-associated protein-14 (S100A9) in gastric cancer and to explore its relationship with the clinicopathological features of gastric cancer. Methods Totally 82 gastric cancer tissues resected by surgery were selected as gastric cancer group and 82 normal gastric cancer tissues were selected as control group. Immunohistochemical SP method was used to detect the expression of S100A9 protein in two groups. The relationship between the S100A9 protein positive rate and clinicopathological features such as gender, age, tumor invasion depth, differentiation degree, lymph node metastasis, pathological stage and tumor diameter were analyzed. Results The positive rate of S100A9 protein in gastric cancer group was 59.8% (49/82) and that in control group was 6.1% (5/82). The positive rate of S100A9 in gastric cancer group was higher than that in control group (P <0.05). The expression of S100A9 protein in stage T3 + T4 of patients with gastric cancer was higher than that in stage T1 + T2, while the expression of S100A9 in poorly differentiated patients was higher than that in patients with high and moderately differentiated tumors. The expression of S100A9 in patients with lymph node metastasis was higher than those without lymph node metastasis S100A9 protein expression in stage Ⅲ + Ⅳ was higher than that in stage Ⅰ + Ⅱ (all P <0.05). Conclusion The expression of S100A9 in gastric cancer tissues was significantly up-regulated, which was related to lymph node metastasis, depth of tumor invasion, clinical stage and differentiation.