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目的对急性冠状动脉(冠脉)综合征患者血浆骨膜蛋白(periostin)水平与血管内皮生长因子(VEGF)、内皮素1(ET-1)、超敏C反应蛋白(hs-CRP)的几项指标之间的相关性进行分析,为今后的临床检验工作提供参考。方法 98例急性冠脉综合征患者(急性冠脉综合征组),将其按照疾病类型分成不稳定型心绞痛组和急性心肌梗死组,每组49例,另外选择同期50例健康体检者作为对照组,对三组受试者展开血浆periostin蛋白水平与VEGF、ET-1及hs-CRP水平检测,并对检测结果进行统计分析。结果急性冠脉综合征组血浆periostin蛋白水平与VEGF、ET-1及hs-CRP水平均高于对照组(P<0.05);急性心肌梗死组患者血浆periostin蛋白水平与VEGF、ET-1及hs-CRP水平高于不稳定型心绞痛组(P<0.05)。结论对血浆periostin蛋白水平与VEGF、ET-1及hs-CRP水平进行联合检测,可为临床急性冠脉综合征诊断、鉴别、病程判断等提供可靠的参考依据,值得关注。
Objective To investigate the relationship between periostin levels and vascular endothelial growth factor (VEGF), endothelin-1 (ET-1) and hs-CRP in patients with acute coronary syndrome (coronary syndrome) Indicators of the correlation between the analysis for future clinical testing provide a reference. Methods A total of 98 patients with acute coronary syndrome (ACS group) were divided into unstable angina pectoris group and acute myocardial infarction group according to disease types, 49 cases in each group. In addition, 50 healthy subjects were selected as controls Group. The plasma periostin level, VEGF, ET-1 and hs-CRP levels in three groups of subjects were measured, and the results were statistically analyzed. Results The levels of periostin, the levels of VEGF, ET-1 and hs-CRP in acute coronary syndrome group were significantly higher than those in control group (P <0.05). The plasma levels of periostin in patients with acute myocardial infarction were significantly correlated with the levels of VEGF, ET- -CRP level was higher than that of unstable angina pectoris group (P <0.05). Conclusion The combination of plasma periostin levels and VEGF, ET-1 and hs-CRP levels may provide reliable reference for the diagnosis, identification and course judgment of clinical acute coronary syndromes.