论文部分内容阅读
目的:考察不同试验方法对头孢氨苄胶囊、阿莫西林胶囊等抗生素溶出度测定结果的影响。方法:采用自身对照法(两种对照溶液配制方法)、对照品对照法测定头孢氨苄、阿莫西林胶囊等抗生素的溶出度。结果:明胶空心胶囊对测定结果有一定影响;阿莫西林胶囊溶出度测定时对照溶液的配制方法对结果有较大影响;自身对照法与对照品对照法的测定结果有一定差异。结论:应该用明胶空心胶囊溶液作为空白溶液以消除来自明胶空心胶囊的影响;应该规范自身对照法中对照溶液的配制方法以保证主药全部溶解;自身对照法与对照品对照法各有利弊,用何方法应按具体情况而定。
Objective: To investigate the influence of different test methods on the determination of antibiotic dissolution of cephalexin capsules and amoxicillin capsules. Methods: The self-control method (two control solution preparation method), the reference substance control method for the determination of cephalexin, amoxicillin capsules and other antibiotics dissolution. Results: The gelatin hollow capsules had a certain effect on the determination results. The formulation of the control solution had a significant effect on the dissolution of amoxicillin capsules. The results of self-control method and control substance were different. Conclusion: The solution of gelatin hollow capsules should be used as a blank solution to eliminate the influence of gelatin hollow capsules. The formulation of the control solution should be regulated in the self-control method to ensure the dissolution of the main drug. There are advantages and disadvantages between the self-control method and the reference substance control method, What method should be used according to the specific circumstances.