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目的探讨组合克罗米芬的超促排卵新方案对体外受精(IVF)中卵巢低反应者的治疗效果。方法选择在IVF治疗过程中发现的卵巢低反应者共24例,先后采用常规短方案超促排卵(常规组)和组合克罗米芬超促排卵(组合组)两次IVF周期治疗。结果组合组较常规组第7天血清雌二醇(E2)浓度及注射人绒毛膜促性腺激素(hCG)日血清E2浓度增高,促性腺激素(Gn)用量减少,注射Gn的天数缩短,胚胎种植率(24.4%vs.6.6%)增高(P<0.05);组合组较常规组临床妊娠率略有增高(29.1%vs.12.5%)(P>0.05)。结论组合克罗米芬的超促排卵方案能改善卵巢低反应者IVF治疗结局,缩短了用Gn的时间,减少了Gn的用量,是一种有效且经济的新方案。
Objective To investigate the therapeutic effect of a combination of clomiphene and a new regimen of ovulation induction on low ovarian responders in in vitro fertilization (IVF). Methods A total of 24 ovarian low responders were selected during the course of IVF treatment. Two cycles of IVF were followed by conventional short protocol superovulation (conventional group) and combination clomiphene hyperoxidation (combination group). Results Compared with the routine group, serum estradiol (E2) concentration and serum E2 level on the day of injection of human chorionic gonadotropin (hCG) were significantly increased, the amount of gonadotropin (Gn) decreased, the number of Gn injection days shortened, The implantation rate (24.4% vs.6.6%) was higher (P <0.05). The clinical pregnancy rate in the combination group was slightly higher than that in the conventional group (29.1% vs. 12.5%) (P> 0.05). Conclusions Combined clomiphene omethoate ovulation regimen can improve IVF outcome in ovarian low responders, shorten Gn time and reduce the dosage of Gn, which is an effective and economical new regimen.