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目的提高对结外鼻型NK/T细胞淋巴瘤的认识。方法报告1例原发于眼眶的NK/T细胞淋巴瘤,结合文献进行分析讨论。结果患者曾被误诊为眼眶炎性假瘤,后经免疫组化确诊为眼眶NK/T细胞淋巴瘤。肿瘤细胞免疫表型为CD56+,CD2+,CD45RO+,CD79a+,CD20-,CD21-,CD38-,CD138-。应用放疗及化疗,患者未能完全缓解,病程中合并噬血细胞综合征,最后死亡。结论眼眶原发性NK/T细胞淋巴瘤罕见,容易误诊,侵袭性强,确诊手段为免疫组化,治疗效果差,预后不良。
Objective To improve the understanding of extranodal nasal type NK / T cell lymphoma. Methods One case of NK / T cell lymphoma originating in the orbit was reported and analyzed in the literature. Results The patient had been misdiagnosed as orbital inflammatory pseudotumor and then confirmed by immunohistochemistry as orbital NK / T cell lymphoma. Tumor cell immunophenotypes were CD56 +, CD2 +, CD45RO +, CD79a +, CD20-, CD21-, CD38-, CD138-. Radiotherapy and chemotherapy, the patient failed to complete remission, the course of the merger hemophagocytic syndrome, and finally died. Conclusions Primary orbital orbital NK / T cell lymphoma is rare, easily misdiagnosed, invasive and confirmatory means immunohistochemistry, the treatment effect is poor, the prognosis is poor.