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目的探讨小剂量阿司匹林(aspirin)在促进诱发排卵过程中对子宫内膜发育的影响。方法2000-09-2003-03郑州大学第三附属医院对不明原因的不孕妇女采用前瞻性随机双盲的方法,在氯米芬(CC)促排卵治疗同时,自月经第1~20天连续服用小剂量阿司匹林75mg/d。结果阿司匹林组的子宫动脉血流阻力指数(RI)明显低于CC组(P<0.01),子宫内膜厚度明显厚于CC组(P<0.01),子宫内膜腺体面积、周长、间质面积、腺/间比值及雌、孕激素受体的数目均明显大于CC组(P<0.01)。排卵前后,阿司匹林组和CC组的E2、P质量浓度均高于对照组,阿司匹林组和CC组的E2、P质量浓度差异无显著性(P>0.05)。结论小剂量阿司匹林可改善促排卵时氯米芬所致的子宫内膜发育不良,但不能改善促排卵治疗时CC所致的内源激素紊乱状态。
Objective To investigate the effect of aspirin (low dose aspirin) on the development of endometrium during ovulation induction. Methods 2000-09-2003-03 Third Affiliated Hospital of Zhengzhou University of unexplained infertility women with a prospective randomized double-blind method, clomiphene (CC) ovulation induction treatment at the same time, 1 to 20 days from the first consecutive days Take a small dose of aspirin 75mg / d. Results The uterine arterial resistance index (RI) in aspirin group was significantly lower than that in CC group (P <0.01), and the thickness of endometrium was significantly thicker than that in CC group (P <0.01). The endometrial gland area, The area of gland, the ratio of gland / gland and the number of estrogen and progesterone receptors were significantly higher than those in CC group (P <0.01). The levels of E2 and P in aspirin group and CC group were higher than those in control group before and after ovulation. There were no significant differences in E2 and P concentrations between aspirin group and CC group (P> 0.05). Conclusions Low-dose aspirin can improve clomiphene-induced endometrial dysplasia during ovulation induction, but it can not improve the endogenous hormone imbalance induced by CC during ovulation induction.