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目的观察血必净注射液辅治对创伤性脓毒症患者血清C反应蛋白(CRP)、白细胞介素-8(IL-8)、白细胞介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)水平的影响。方法将创伤性脓毒症患者208例随机分为研究组与对照组各104例,2组患者入院后均给予积极的外科手术清创、行积极的液体复苏治疗、抗生素控制感染、给予积极的镇静、镇痛处理及器官功能保护等综合处理。研究组在此基础上给予加用血必净注射液100ml静脉滴注,每天2次。对照组同期给予葡萄糖氯化钠注射液100ml静脉滴注。治疗后第5天晨空腹静脉血测血清CRP、IL-8、IL-10、TNF-α水平的变化。结果术后第5天研究组血清CRP、IL-8、IL-10、TNF-α水平明显低于对照组,差异均有统计学意义(P<0.05)。结论创伤性脓毒症患者早期给予血必净注射液辅助治疗可明显减轻患者血清炎性反应细胞因子水平,减少炎性损伤,对各脏器功能具有保护作用。
Objective To observe the effects of Xuebijing injection on the levels of serum C-reactive protein (CRP), interleukin-8 (IL-8), interleukin-10 (IL-10), tumor necrosis factor- α (TNF-α) levels. Methods 208 patients with traumatic sepsis were randomly divided into study group and control group, 104 cases. Two groups of patients were given positive surgical debridement after active admission. Positive liquid resuscitation was performed. Antibiotics was used to control infection and positive Sedation, analgesic treatment and organ function protection and other comprehensive treatment. On the basis of this study, the study group was given intravenous infusion of Xuebijing injection 100ml twice daily. The control group was given intravenous infusion of glucose and sodium chloride injection 100ml over the same period. The changes of serum CRP, IL-8, IL-10 and TNF-α in the morning fasting venous blood samples were measured on the fifth day after treatment. Results The serum levels of CRP, IL-8, IL-10 and TNF-α in the study group were significantly lower than those in the control group on the 5th postoperative day (P <0.05). Conclusion The adjuvant treatment with Xuebijing injection in patients with traumatic sepsis can reduce the levels of serum inflammatory cytokines, reduce the inflammatory injury and protect the function of various organs.