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目的:探讨丹参酮胶囊联合米索前列醇对产后宫腔积血患者的临床疗效。方法:选取88例产后宫腔积血患者,采用随机数字表随机分为对照组及治疗组。两组均予米索前列醇治疗,治疗组再予丹参酮胶囊治疗。观察两组治疗前后子宫复旧情况及生活质量,评估其安全性及临床疗效。结果:总有效率对照组为75.0%,治疗组为93.2%,组间比较,差异有统计学意义(P<0.05)。治疗后两组患者子宫长径、横径、前后径均短于同组治疗前(P<0.05);治疗后治疗组患者子宫长径、横径、前后径均短于同期对照组(P<0.05)。治疗后两组患者疼痛/不舒服、行动能力、自我照顾能力、日常活动能力、焦虑/抑郁评分均高于同组治疗前(P<0.01);治疗后治疗组患者疼痛/不舒服评分高于同期对照组(P<0.05)。两组治疗过程中未发现严重不良反应事件。结论:丹参酮胶囊联合米索前列醇治疗产后宫腔积血患者,疗效显著;可有效减轻患者产后疼痛/不适感,提高患者产后生活质量。
Objective: To investigate the clinical effect of tanshinone capsules combined with misoprostol on postpartum patients with uterine hemorrhage. Methods: 88 cases of postpartum uterine hemorrhage patients were randomly divided into control group and treatment group using random number table. Two groups were treated with misoprostol, the treatment group was treated with tanshinone capsules. Observation of the two groups before and after treatment of uterine involution and quality of life, to assess its safety and clinical efficacy. Results: The total effective rate was 75.0% in the control group and 93.2% in the treatment group. There was significant difference between the two groups (P <0.05). After treatment, the long diameter, transverse diameter and anteroposterior diameter of the uterus in both groups were shorter than those in the same group before treatment (P <0.05). After treatment, the long diameter, transverse diameter and anteroposterior diameter of the uterus in the treatment group were shorter than those in the control group (P < 0.05). After treatment, the scores of pain / discomfort, mobility, self-care ability, daily activities and anxiety / depression scores of the two groups were significantly higher than those before treatment (P <0.01); the pain / discomfort scores of the treatment group were higher than The same period control group (P <0.05). No serious adverse events were found during the two groups. Conclusion: Tanshinone capsules combined with misoprostol for treatment of postpartum uterine hemorrhage in patients with significant effect; can effectively reduce postpartum pain / discomfort and improve post-natal life quality of patients.