目的探讨血清学降钙素原(PCT)在新生儿败血症早期诊断的意义。方法对我院新生儿科的112例新生儿进行PCT的测定,分为败血症确诊组(A组)30例,临床败血症组(B组)52例和非感染组(C组)30例三组进行分析。结果当PCT>2ng/ml时,新生儿败血症组(A+B组)与非感染组(C组)相比有显著的统计学意义(χ2=28.01,P<0.01),按PCT>2ng/ml为界点,PCT-Q法与血培养结果比较有显著性差异(χ2=14.45,P<0.01)。结论细菌感染时血清PCT早期即升高,可作为新生儿败血症早期诊断有价值的指标。 Objective To investigate the significance of serum procalcitonin (PCT) in the early diagnosis of neonatal sepsis. Methods One hundred and twelve newborns of neonatology in our hospital were tested for PCT. Thirty patients with confirmed sepsis (group A), 30 patients with clinical sepsis (group B) and 30 patients with non-infected group (group C) analysis. Results When PCT> 2ng / ml, there was significant difference between neonatal sepsis group (A + B group) and noninfected group (C group) (χ2 = 28.01, P <0.01) ml as the cutoff point. There was significant difference between PCT-Q and blood culture results (χ2 = 14.45, P <0.01). Conclusions Serum PCT increased at early stage of bacterial infection and could be used as a valuable index in the early diagnosis of neonatal sepsis.